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Transition to Metabolic Constraint Collectively, GLP-1RA therapy is characterized by persistent reductions in nutrient inflow, increased reliance on lipid-derived substrates, suppression of anabolic pathways through AMPK signaling, and context-dependent modulation of adipose tissue lipolysis

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The trial included a non-alcoholic fatty liver disease (NAFLD) cohort, where the drug helped patients reduce liver fat and improve insulin sensitivity